What is a Neurotoxin? Is it the Same Thing as BOTOX?

Neurotoxins, such as BOTOX®, Dysport®, Xeomin®, and Jeuveau, are purified proteins derived from the bacterium Clostridium botulinum. When injected into specific muscles, these neurotoxins block the release of acetylcholine, a neurotransmitter responsible for muscle contraction. By temporarily paralyzing the targeted muscles, neurotoxins can reduce the appearance of wrinkles caused by repeated muscle movements.

While BOTOX® (onabotulinumtoxinA) was the first neurotoxin approved for cosmetic use, Jeuveau (prabotulinumtoxinA-xvfs) is a newer formulation that works similarly but has some differences in its molecular structure and manufacturing process.

How Often Do You Have to Get BOTOX® or Jeuveau to Get the Full Benefits?

The effects of neurotoxins like BOTOX® and Jeuveau typically last for 3-4 months, after which the muscles gradually regain their ability to contract, and wrinkles may reappear. To maintain the desired results, most patients need to receive regular treatments every 3-4 months.

Can I Make BOTOX® or Jeuveau Last Longer?

While there is no guaranteed way to extend the longevity of neurotoxin treatments, some factors may influence their duration:

• Metabolic Rate: Individuals with slower metabolisms may experience longer-lasting effects.
• Dosage: Higher doses of neurotoxins may last slightly longer, but this should be discussed with your provider to avoid potential side effects.
• Muscle Mass: Larger muscles may require higher doses or more frequent treatments.
• Lifestyle Factors: Avoiding activities that increase muscle movement (e.g., excessive squinting, frowning) can help prolong the effects.

Can Starting and Stopping Neuromodulator Treatment Cause Problems?

It is generally safe to start and stop neurotoxin treatments as desired. However, some patients may experience a temporary exaggeration of wrinkles or muscle movements when resuming treatment after a prolonged break. This is usually temporary and resolves within a few treatments. Read More

What is the Difference Between BOTOX®, Dysport®, Xeomin®, and Jeuveau?

While all four neurotoxins are derived from the same bacterium and work in a similar manner, there are some key differences:

• Brand Name: BOTOX® (onabotulinumtoxinA), Dysport® (abobotulinumtoxinA), Xeomin® (incobotulinumtoxinA), and Jeuveau (prabotulinumtoxinA-xvfs).
• Formulation: Each neurotoxin has a slightly different molecular structure and manufacturing process, which can affect potency, diffusion, and onset of action.
• Approved Uses: While all are approved for treating glabellar lines, some have additional approved uses (e.g., BOTOX® for chronic migraine, hyperhidrosis, and other conditions).
• Dosing Units: The dosing units for each neurotoxin are different and not interchangeable.

Comparing the Cost of BOTOX® and Jeuveau

The cost of neurotoxin treatments can vary depending on several factors, including the provider, location, and the number of units required. Generally, Jeuveau is priced lower than BOTOX®, making it a more affordable option for some patients.

It’s important to note that while cost is a consideration, the provider’s experience and technique are crucial in achieving optimal results and minimizing potential side effects.

Should I be Concerned When I See Discounted Specials?

While discounted specials can be tempting, it’s essential to exercise caution when considering deeply discounted neurotoxin treatments. Some potential concerns include:

• Diluted or Counterfeit Products: Unscrupulous providers may dilute or use counterfeit products to offer lower prices, compromising safety and efficacy.
• Untrained Providers: Deeply discounted treatments may be offered by providers with inadequate training or experience.
• Unsanitary Conditions: Cost-cutting measures may lead to unsanitary conditions or improper handling of the neurotoxin.

It’s generally recommended to prioritize safety and quality over heavily discounted prices, especially when it comes to injectable treatments.

What Happens if I Change to a Different Neurotoxin?

If you decide to switch from one neurotoxin to another (e.g., from BOTOX® to Jeuveau), it’s essential to inform your provider and allow sufficient time for the previous neurotoxin to fully metabolize. Your provider may need to adjust the dosage and injection technique to account for the differences between the products.

Switching neurotoxins is generally safe, but it’s crucial to follow your provider’s guidance to ensure optimal results and minimize the risk of side effects.

Jeuveau vs. Botox: Overview

	Jeuveau	BOTOX®
FDA Approval	Approved in 2019 for glabellar lines	Approved in 2002 for glabellar lines, other medical uses
Manufacturer	Evolus	Allergan (now part of AbbVie)
Active Ingredient	PrabotulinumtoxinA-xvfs	OnabotulinumtoxinA
Pricing	Generally lower than BOTOX®	Higher pricing, varies by location

Jeuveau vs. Botox: Similarities and Differences

While Jeuveau and BOTOX® share similarities as neurotoxins, there are some key differences to consider.

FDA Approval

• Jeuveau: Approved by the FDA in 2019 for the temporary improvement of moderate to severe glabellar lines in adults.
• BOTOX®: Initially approved by the FDA in 2002 for glabellar lines and has since gained approval for various medical uses, including chronic migraine, overactive bladder, and excessive sweating.

Formulation

• Jeuveau: Contains the active ingredient prabotulinumtoxinA-xvfs, which is a purified form of the botulinum toxin derived from the Clostridium botulinum bacteria.
• BOTOX®: Contains the active ingredient onabotulinumtoxinA, which is also a purified form of the botulinum toxin but with a slightly different molecular structure.

Use Cases

• Jeuveau: Currently approved only for the temporary improvement of moderate to severe glabellar lines in adults.
• BOTOX®: Approved for a broader range of medical and cosmetic uses, including glabellar lines, chronic migraine, overactive bladder, excessive sweating, and other conditions.

While both Jeuveau and BOTOX® are effective in treating glabellar lines, BOTOX® has a longer track record and more diverse approved uses due to its earlier FDA approval and extensive research.

Conclusion

Jeuveau is a newer neurotoxin that offers an alternative to BOTOX® for treating glabellar lines. While both products work by temporarily paralyzing the targeted muscles, they differ in their molecular structure, pricing, and approved uses.

Ultimately, the choice between Jeuveau and BOTOX® will depend on individual factors such as cost, personal preferences, and the specific concerns being addressed. It’s essential to consult with a qualified and experienced provider who can assess your unique needs and provide guidance on the most appropriate treatment option.

Remember, neurotoxin treatments should always be administered by licensed and trained professionals in a safe and controlled environment. Prioritizing safety